Family-based gene-environment interaction using sequence kernel association test (FGE-SKAT) for complex quantitative traits
نویسندگان
چکیده
منابع مشابه
Sequence Kernel Association Test, gene-environment interaction test, and meta-analysis for family samples with repeated measurements or multiple traits
Genetic loci identified by single variant association tests account for only a small proportion of the heritability for most complex traits and diseases. Part of the unexplained heritability may be due to rare variants and their interactions with environmental factors. Different strategies have been taken to increase the power to detect genetic associations, such as increasing the sample size b...
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*These authors contributed equally to this work. 1 Department of Biostatistics, The University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA 2 Department of Biostatistics, Harvard School of Public Health, Boston, MA 02115, USA 3 Department of Genetics, The University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA 4 Department of Biostatistics and Center for Statisti...
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ژورنال
عنوان ژورنال: Scientific Reports
سال: 2021
ISSN: 2045-2322
DOI: 10.1038/s41598-021-86871-2